Ontology highlight
ABSTRACT:
SUBMITTER: Liu R
PROVIDER: S-EPMC5805723 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Liu Rengyun R Zhang Tao T Zhu Guangwu G Xing Mingzhao M
Nature communications 20180208 1
The unique oncogene duet of coexisting BRAF V600E and TERT promoter mutations are widely found to be a robust genetic background promoting human cancer aggressiveness, but the mechanism is unclear. Here, we demonstrate that the BRAF V600E/MAP kinase pathway phosphorylates and activates FOS, which in turn acts as a transcription factor to bind and activate the GABPB promoter, increasing GABPB expression and driving formation of GABPA-GABPB complex; the latter selectively binds and activates mutan ...[more]