Ontology highlight
ABSTRACT:
SUBMITTER: Ginart AA
PROVIDER: S-EPMC5805770 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Ginart Antonio A AA Hui Joseph J Zhu Kaiyuan K Numanagić Ibrahim I Courtade Thomas A TA Sahinalp S Cenk SC Tse David N DN
Nature communications 20180208 1
The most effective genomic data compression methods either assemble reads into contigs, or replace them with their alignment positions on a reference genome. Such methods require significant computational resources, but faster alternatives that avoid using explicit or de novo-constructed references fail to match their performance. Here, we introduce a new reference-free compressed representation for genomic data based on light de novo assembly of reads, where each read is represented as a node i ...[more]