No genetic association between A118G polymorphism of μ-opioid receptor gene and schizophrenia and bipolar disorders.

ABSTRACT:

Background

Schizophrenia (SZ) and bipolar disorder (BD) are chronic and multifactorial psychiatric disorders that might be affected by different genes in combination with environmental factors. There is evidence of association between polymorphisms of μ-opioid receptor gene (OPRM1) with these disorders.

Objectives

The aim of this study was to investigate the genetic association between OPRM1 A118G SNP in SZ and BD patients in comparison with healthy controls (HCs).

Materials and methods

One single-nucleotide polymorphism in OPRM1 was genotyped using TaqMan real-time PCR assay in 203 SZ and BD patients and 389 HCs.

Results

There was no statistically significant difference in genotypic and allelic frequencies of OPRM1 A118G SNP between HCs and SZ/BD patients.

SUBMITTER: Yazdani S 

PROVIDER: S-EPMC5806329 | biostudies-literature | 2017 Oct-Dec

REPOSITORIES: biostudies-literature