Trimethoprim use for urinary tract infection and risk of adverse outcomes in older patients: cohort study.

ABSTRACT:

Objective

To determine if trimethoprim use for urinary tract infection (UTI) is associated with an increased risk of acute kidney injury, hyperkalaemia, or sudden death in the general population.

Design

Cohort study.

Setting

UK electronic primary care records from practices contributing to the Clinical Practice Research Datalink linked to the Hospital Episode Statistics database.

Participants

Adults aged 65 and over with a prescription for trimethoprim, amoxicillin, cefalexin, ciprofloxacin, or nitrofurantoin prescribed up to three days after a primary care diagnosis of UTI between April 1997 and September 2015.

Main outcome measures

The outcomes were acute kidney injury, hyperkalaemia, and death within 14 days of a UTI treated with antibiotics.

Resul

SUBMITTER: Crellin E 

PROVIDER: S-EPMC5806507 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature