Ontology highlight
ABSTRACT:
SUBMITTER: Chinta SJ
PROVIDER: S-EPMC5806534 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Chinta Shankar J SJ Woods Georgia G Demaria Marco M Rane Anand A Zou Ying Y McQuade Amanda A Rajagopalan Subramanian S Limbad Chandani C Madden David T DT Campisi Judith J Andersen Julie K JK
Cell reports 20180128 4
Exposure to the herbicide paraquat (PQ) is associated with an increased risk of idiopathic Parkinson's disease (PD). Therapies based on PQ's presumed mechanisms of action have not, however, yielded effective disease therapies. Cellular senescence is an anticancer mechanism that arrests proliferation of replication-competent cells and results in a pro-inflammatory senescence-associated secretory phenotype (SASP) capable of damaging neighboring tissues. Here, we demonstrate that senescent cell mar ...[more]