Ontology highlight
ABSTRACT:
SUBMITTER: Chen YH
PROVIDER: S-EPMC5806629 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Chen Yen-Hua YH Kratchmarov Radomir R Lin Wen-Hsuan W WW Rothman Nyanza J NJ Yen Bonnie B Adams William C WC Nish Simone A SA Rathmell Jeffrey C JC Reiner Steven L SL
Cell reports 20180128 4
Unequal transmission of nutritive signaling during cell division establishes fate disparity between sibling lymphocytes, but how asymmetric signaling becomes organized is not understood. We show that receptor-associated class I phosphatidylinositol 3-kinase (PI3K) signaling activity, indexed by phosphatidylinositol (3,4,5)-trisphosphate (PIP<sub>3</sub>) staining, is spatially restricted to the microtubule-organizing center and subsequently to one pole of the mitotic spindle in activated T and B ...[more]