Ontology highlight
ABSTRACT:
SUBMITTER: Shichino Y
PROVIDER: S-EPMC5807050 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Shichino Yuichi Y Otsubo Yoko Y Kimori Yoshitaka Y Yamamoto Masayuki M Yamashita Akira A
eLife 20180209
Accurate and extensive regulation of meiotic gene expression is crucial to distinguish germ cells from somatic cells. In the fission yeast <i>Schizosaccharomyces pombe,</i> a YTH family RNA-binding protein, Mmi1, directs the nuclear exosome-mediated elimination of meiotic transcripts during vegetative proliferation. Mmi1 also induces the formation of facultative heterochromatin at a subset of its target genes. Here, we show that Mmi1 prevents the mistimed expression of meiotic proteins by tether ...[more]