Robo1 Forms a Compact Dimer-of-Dimers Assembly.
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ABSTRACT:
SUBMITTER: Aleksandrova N
PROVIDER: S-EPMC5807052 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Robo1 Forms a Compact Dimer-of-Dimers Assembly.
Aleksandrova Nataliia N Gutsche Irina I Kandiah Eaazhisai E Avilov Sergiy V SV Petoukhov Maxim V MV Seiradake Elena E McCarthy Andrew A AA
Structure (London, England : 1993) 20180104 2
Roundabout (Robo) receptors provide an essential repulsive cue in neuronal development following Slit ligand binding. This important signaling pathway can also be hijacked in numerous cancers, making Slit-Robo an attractive therapeutic target. However, little is known about how Slit binding mediates Robo activation. Here we present the crystal structure of Robo1 Ig1-4 and Robo1 Ig5, together with a negative stain electron microscopy reconstruction of the Robo1 ectodomain. These results show how ...[more]
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