Allostatic load but not medical burden predicts memory performance in late-life bipolar disorder.

ABSTRACT: OBJECTIVE:Older patients with bipolar disorder (BD) present with variable degrees of cognitive impairment. Over time, stress, mood episodes, and comorbidities increase the body's allostatic load. We assessed the extent to which allostatic load vs more traditional measures of medical burden account for the heterogeneity in cognition in this population. METHODS:Thirty-five older euthymic patients with BD and 30 age-equated, gender-equated, and education-equated comparison participants were administered a comprehensive assessment including a neuropsychological battery, and 9 physiological measures to determine allostatic load. The relationship among allostatic load, medical burden, and cognition was assessed. RESULTS:Compared with the mentally healthy comparators, patients were impaired globa

SUBMITTER: Vaccarino SR 

PROVIDER: S-EPMC5807161 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature