Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry.
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ABSTRACT:
SUBMITTER: Freund-Brown J
PROVIDER: S-EPMC5807242 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry.
Freund-Brown Jacquelyn J Choa Ruth R Singh Brenal K BK Robertson Tanner Ford TF Ferry Gabrielle M GM Viver Eric E Bassiri Hamid H Burkhardt Janis K JK Kambayashi Taku T
Journal of immunology (Baltimore, Md. : 1950) 20170809
Sustained Ca<sup>2+</sup> signaling, known as store-operated calcium entry (SOCE), occurs downstream of immunoreceptor engagement and is critical for cytotoxic lymphocyte signaling and effector function. CD8<sup>+</sup> T cells require sustained Ca<sup>2+</sup> signaling for inflammatory cytokine production and the killing of target cells; however, much less is known about its role in NK cells. In this study, we use mice deficient in stromal interacting molecules 1 and 2, which are required for ...[more]
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