Ontology highlight
ABSTRACT:
SUBMITTER: Sonke GS
PROVIDER: S-EPMC5807486 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Sonke Gabe S GS Hart Lowell L LL Campone Mario M Erdkamp Frans F Janni Wolfgang W Verma Sunil S Villanueva Cristian C Jakobsen Erik E Alba Emilio E Wist Erik E Favret Anne M AM Bachelot Thomas T Hegg Roberto R Wheatley-Price Paul P Souami Farida F Sutradhar Santosh S Miller Michelle M Germa Caroline C Burris Howard A HA
Breast cancer research and treatment 20171022 3
<h4>Purpose</h4>Determine the efficacy and safety of first-line ribociclib plus letrozole in elderly patients with HR+, HER2- advanced breast cancer.<h4>Methods</h4>668 postmenopausal women with HR+, HER2- advanced breast cancer and no prior systemic therapy for advanced disease were enrolled in the Phase III MONALEESA-2 trial (NCT01958021); 295 patients were aged ≥ 65 years. Patients were randomized to ribociclib (600 mg/day; 3-weeks-on/1-week-off) plus letrozole (2.5 mg/day) or placebo plus le ...[more]