Ontology highlight
ABSTRACT:
SUBMITTER: Ebner P
PROVIDER: S-EPMC5807552 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Ebner Petra P Poetsch Isabella I Deszcz Luiza L Hoffmann Thomas T Zuber Johannes J Ikeda Fumiyo F
Nature communications 20180209 1
Autophagy has an important role in cellular homeostasis by degrading and recycling cytotoxic components. Ubiquitination is known to target cargoes for autophagy; however, key components of this pathway remain elusive. Here we performed an RNAi screen to uncover ubiquitin modifiers that are required for starvation-induced macroautophagy in mammalian cells. Our screen uncovered BRUCE/Apollon/Birc6, an IAP protein, as a new autophagy regulator. Depletion of BRUCE leads to defective fusion of autoph ...[more]