Ontology highlight
ABSTRACT:
SUBMITTER: Klymenko T
PROVIDER: S-EPMC5808072 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Klymenko T T Bloehdorn J J Bahlo J J Robrecht S S Akylzhanova G G Cox K K Estenfelder S S Wang J J Edelmann J J Strefford J C JC Wojdacz T K TK Fischer K K Hallek M M Stilgenbauer S S Cragg M M Gribben J J Braun A A Braun A A
Leukemia 20170814 2
Somatic hypermutation (SHM) is a pivotal process in adaptive immunity that occurs in the germinal centre and allows B cells to change their primary DNA sequence and diversify their antigen receptors. Here, we report that genome binding of Lamin B1, a component of the nuclear envelope involved in epigenetic chromatin regulation, is reduced during B-cell activation and formation of lymphoid germinal centres. Chromatin immunoprecipitation-Seq analysis showed that kappa and heavy variable immunoglob ...[more]