Ontology highlight
ABSTRACT:
SUBMITTER: Seok SH
PROVIDER: S-EPMC5808761 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Seok Seung-Hyeon SH Ma Zhi-Xiong ZX Feltenberger John B JB Chen Hongbo H Chen Hui H Scarlett Cameron C Lin Ziqing Z Satyshur Kenneth A KA Cortopassi Marissa M Jefcoate Colin R CR Ge Ying Y Tang Weiping W Bradfield Christopher A CA Xing Yongna Y
The Journal of biological chemistry 20171226 6
Cellular metabolites act as important signaling cues, but are subject to complex unknown chemistry. Kynurenine is a tryptophan metabolite that plays a crucial role in cancer and the immune system. Despite its atypical, non-ligand-like, highly polar structure, kynurenine activates the aryl hydrocarbon receptor (AHR), a PER, ARNT, SIM (PAS) family transcription factor that responds to diverse environmental and cellular ligands. The activity of kynurenine is increased 100-1000-fold by incubation or ...[more]