Ontology highlight
ABSTRACT:
SUBMITTER: Grebely J
PROVIDER: S-EPMC5808802 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Grebely Jason J Feld Jordan J JJ Wyles David D Sulkowski Mark M Ni Liyun L Llewellyn Joe J Mir Heshaam M HM Sajed Nika N Stamm Luisa M LM Hyland Robert H RH McNally John J Brainard Diana M DM Jacobson Ira I Zeuzem Stefan S Bourlière Marc M Foster Graham G Afdhal Nezam N Dore Gregory J GJ
Open forum infectious diseases 20180209 2
<h4>Background</h4>Hepatitis C virus (HCV) direct-acting antiviral therapy is effective among people receiving opioid substitution therapy (OST), but studies are limited by small numbers of nongenotype 1 (GT1) patients. The aim of this study was to evaluate the treatment completion, adherence, SVR12, and safety of sofosbuvir-based therapies in HCV patients receiving and not receiving OST.<h4>Methods</h4>Ten phase 3 studies of sofosbuvir-based regimens included ION (ledipasvir/sofosbuvir ± ribavi ...[more]