Ontology highlight
ABSTRACT:
SUBMITTER: Ji C
PROVIDER: S-EPMC5808879 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20150208 3
Syntheses of two Siderophore-fluoroquinolone conjugates with a potential reduction triggered linker for drug release are described. The "trimethyl lock" based linker incorporated in the conjugates was designed to be activated by taking advantage of the reductive pathway of bacterial iron metabolism. Electrochemical and LC-MS studies indicated that the linker is thermodynamically reducible by common biological reductants and the expected lactonization proceeds rapidly with concomitant release of ...[more]