Mediation analysis for logistic regression with interactions: Application of a surrogate marker in ophthalmology.
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ABSTRACT:
SUBMITTER: Jensen SM
PROVIDER: S-EPMC5809055 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Mediation analysis for logistic regression with interactions: Application of a surrogate marker in ophthalmology.
Jensen Signe M SM Hauger Hanne H Ritz Christian C
PloS one 20180212 2
Mediation analysis is often based on fitting two models, one including and another excluding a potential mediator, and subsequently quantify the mediated effects by combining parameter estimates from these two models. Standard errors of such derived parameters may be approximated using the delta method. For a study evaluating a treatment effect on visual acuity, a binary outcome, we demonstrate how mediation analysis may conveniently be carried out by means of marginally fitted logistic regressi ...[more]
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