Differential microstructural alterations in rat cerebral cortex in a model of chronic mild stress depression.

ABSTRACT: Chronic mild stress leads to depression in many cases and is linked to several debilitating diseases including mental disorders. Recently, neuronal tracing techniques, stereology, and immunohistochemistry have revealed persistent and significant microstructural alterations in the hippocampus, hypothalamus, prefrontal cortex, and amygdala, which form an interconnected system known as the stress circuit. Most studies have focused only on this circuit, however, some studies indicate that manipulation of sensory and motor systems may impact genesis and therapy of mood disorders and therefore these areas should not be neglected in the study of brain microstructure alterations in response to stress and depression. For this reason, we explore the microstructural alterations in different cortical

SUBMITTER: Khan AR 

PROVIDER: S-EPMC5809082 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature