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The fungal pathogen Magnaporthe oryzae suppresses innate immunity by modulating a host potassium channel.


ABSTRACT: Potassium (K+) is required by plants for growth and development, and also contributes to immunity against pathogens. However, it has not been established whether pathogens modulate host K+ signaling pathways to enhance virulence and subvert host immunity. Here, we show that the effector protein AvrPiz-t from the rice blast pathogen Magnaporthe oryzae targets a K+ channel to subvert plant immunity. AvrPiz-t interacts with the rice plasma-membrane-localized K+ channel protein OsAKT1 and specifically suppresses the OsAKT1-mediated K+ currents. Genetic and phenotypic analyses show that loss of OsAKT1 leads to decreased K+ content and reduced resistance against M. oryzae. Strikingly, AvrPiz-t interferes with the association of OsAKT1 with its upstream regulator, the cytoplasmic kinase OsCIPK23, which also plays a positive role in K+ absorption and resistance to M. oryzae. Furthermore, we show a direct correlation between blast disease resistance and external K+ status in rice plants. Together, our data present a novel mechanism by which a pathogen suppresses plant host immunity by modulating a host K+ channel.

SUBMITTER: Shi X 

PROVIDER: S-EPMC5809103 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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The fungal pathogen Magnaporthe oryzae suppresses innate immunity by modulating a host potassium channel.

Shi Xuetao X   Long Yu Y   He Feng F   Zhang Chongyang C   Wang Ruyi R   Zhang Ting T   Wu Wei W   Hao Zeyun Z   Wang Yi Y   Wang Guo-Liang GL   Ning Yuese Y  

PLoS pathogens 20180131 1


Potassium (K+) is required by plants for growth and development, and also contributes to immunity against pathogens. However, it has not been established whether pathogens modulate host K+ signaling pathways to enhance virulence and subvert host immunity. Here, we show that the effector protein AvrPiz-t from the rice blast pathogen Magnaporthe oryzae targets a K+ channel to subvert plant immunity. AvrPiz-t interacts with the rice plasma-membrane-localized K+ channel protein OsAKT1 and specifical  ...[more]

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