Ontology highlight
ABSTRACT:
SUBMITTER: Isharwal S
PROVIDER: S-EPMC5809230 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Isharwal Sumit S Audenet François F Drill Esther E Pietzak Eugene J EJ Iyer Gopa G Ostrovnaya Irina I Cha Eugene E Donahue Timothy T Arcila Maria M Jayakumaran Gowtham G Berger Michael F MF Rosenberg Jonathan E JE Bajorin Dean F DF Coleman Jonathan J Dalbagni Guido G Reuter Victor E VE Bochner Bernard H BH Solit David B DB Al-Ahmadie Hikmat A HA
European urology focus 20170810 2
Point mutations in the TERT gene promoter occur at high frequency in multiple cancers, including urothelial carcinoma (UC). However, the relationship between TERT promoter mutations and UC patient outcomes is unclear due to conflicting reports in the literature. In this study, we examined the association of TERT alterations, tumor mutational burden per megabase (Mb), and copy number alteration (CNA) burden with clinical parameters and their prognostic value in a cohort of 398 urothelial tumors. ...[more]