Ontology highlight
ABSTRACT:
SUBMITTER: Burrack AL
PROVIDER: S-EPMC5809255 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Burrack Adam L AL Landry Laurie G LG Siebert Janet J Coulombe Marilyne M Gill Ronald G RG Nakayama Maki M
Journal of immunology (Baltimore, Md. : 1950) 20180108 4
The autoimmune condition is a primary obstacle to inducing tolerance in type 1 diabetes patients receiving allogeneic pancreas transplants. It is unknown how autoreactive T cells that recognize self-MHC molecules contribute to MHC-disparate allograft rejection. In this report, we show the presence and accumulation of dual-reactive, that is autoreactive and alloreactive, T cells in C3H islet allografts that were transplanted into autoimmune diabetic NOD mice. Using high-throughput sequencing, we ...[more]