Ontology highlight
ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC5809592 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Wu Junhua J Li Pengfei P Dong Chenling C Jiang Heting H Bin Xue Gao Xiang X Qin Meng M Wang Wei W Bin Chen Cao Yi Y
Nature communications 20180212 1
Designing synthetic protein hydrogels with tailored mechanical properties similar to naturally occurring tissues is an eternal pursuit in tissue engineering and stem cell and cancer research. However, it remains challenging to correlate the mechanical properties of protein hydrogels with the nanomechanics of individual building blocks. Here we use single-molecule force spectroscopy, protein engineering and theoretical modeling to prove that the mechanical properties of protein hydrogels are pred ...[more]