Ontology highlight
ABSTRACT:
SUBMITTER: Rizzi G
PROVIDER: S-EPMC5810360 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Rizzi Giovanni G Lee Jung-Rok JR Dahl Christina C Guldberg Per P Dufva Martin M Wang Shan X SX Hansen Mikkel F MF
ACS nano 20170913 9
Epigenetic modifications, in particular DNA methylation, are gaining increasing interest as complementary information to DNA mutations for cancer diagnostics and prognostics. We introduce a method to simultaneously profile DNA mutation and methylation events for an array of sites with single site specificity. Genomic (mutation) or bisulphite-treated (methylation) DNA is amplified using nondiscriminatory primers, and the amplicons are then hybridized to a giant magnetoresistive (GMR) biosensor ar ...[more]