Ontology highlight
ABSTRACT:
SUBMITTER: White KL
PROVIDER: S-EPMC5810373 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
White Kate L KL Eddy Matthew T MT Gao Zhan-Guo ZG Han Gye Won GW Lian Tiffany T Deary Alexander A Patel Nilkanth N Jacobson Kenneth A KA Katritch Vsevolod V Stevens Raymond C RC
Structure (London, England : 1993) 20180127 2
Sodium ions are endogenous allosteric modulators of many G-protein-coupled receptors (GPCRs). Mutation of key residues in the sodium binding motif causes a striking effect on G-protein signaling. We report the crystal structures of agonist complexes for two variants in the first sodium coordination shell of the human A<sub>2A</sub> adenosine receptor, D52<sup>2.50</sup>N and S91<sup>3.39</sup>A. Both structures present an overall active-like conformation; however, the variants show key changes i ...[more]