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Dataset of human medial temporal lobe single neuron activity during declarative memory encoding and recognition.


ABSTRACT: We present a dataset of 1,576 single neurons recorded from the human amygdala and hippocampus in 65 sessions from 42 patients undergoing intracranial monitoring for localization of epileptic seizures. Subjects performed a recognition memory task with pictures as stimuli. Subjects were asked to identify whether they had seen a particular image the first time ('new') or second time ('old') on a 1-6 confidence scale. This comprehensive dataset includes the spike times of all neurons and their extracellular waveforms, behavior, electrode locations determined from post-operative MRI scans, demographics, and the stimuli shown. As technical validation, we provide spike sorting quality metrics and assessment of tuning of cells to verify the presence of visually-and memory selective cells. We also provide analysis code that reproduces key scientific findings published previously on a smaller version of this dataset. Together, this large dataset will facilitate the investigation of the neural mechanism of declarative memory by providing a substantial number of hard to obtain human single-neuron recordings during a well characterized behavioral task.

SUBMITTER: Faraut MCM 

PROVIDER: S-EPMC5810422 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Dataset of human medial temporal lobe single neuron activity during declarative memory encoding and recognition.

Faraut Mailys C M MCM   Carlson April A AA   Sullivan Shannon S   Tudusciuc Oana O   Ross Ian I   Reed Chrystal M CM   Chung Jeffrey M JM   Mamelak Adam N AN   Rutishauser Ueli U  

Scientific data 20180213


We present a dataset of 1,576 single neurons recorded from the human amygdala and hippocampus in 65 sessions from 42 patients undergoing intracranial monitoring for localization of epileptic seizures. Subjects performed a recognition memory task with pictures as stimuli. Subjects were asked to identify whether they had seen a particular image the first time ('new') or second time ('old') on a 1-6 confidence scale. This comprehensive dataset includes the spike times of all neurons and their extra  ...[more]

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