Ontology highlight
ABSTRACT:
SUBMITTER: Pal S
PROVIDER: S-EPMC5810620 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Pal Sangita S Postnikoff Spike D SD Chavez Myrriah M Tyler Jessica K JK
Science advances 20180207 2
The causal relationship between genomic instability and replicative aging is unclear. We reveal here that genomic instability at the budding yeast ribosomal DNA (rDNA) locus increases during aging, potentially due to the reduced cohesion that we uncovered during aging caused by the reduced abundance of multiple cohesin subunits, promoting increased global chromosomal instability. In agreement, cohesion is lost during aging at other chromosomal locations in addition to the rDNA, including centrom ...[more]