Ontology highlight
ABSTRACT:
SUBMITTER: Zheng S
PROVIDER: S-EPMC5810846 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Zheng Shilong S Liu Jiawang J Wu Yanyuan Y Huang Tien L TL Wang Guangdi G
Future medicinal chemistry 20151216 18
<h4>Background</h4>The Wnt signaling pathway involves secreted glycoproteins that bind to the Frizzled family receptors to activate intracellular signal transduction events that regulate cell proliferation, apoptosis, cell migration and many critical aspects of developmental biology.<h4>Discussion</h4>Aberrant Wnt signaling underlies a wide range of pathologies in humans including tumor initiation, tumor growth, cell senescence, cell death, differentiation and metastasis. The inhibition of Wnt s ...[more]