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Diastereoselective synthesis of chiral 1,3-cyclohexadienals.

ABSTRACT: A novel approach to the production of chiral 1,3-cyclohexadienals has been developed. The organocatalysed asymmetric reaction of different β-disubstituted-α,β-unsaturated aldehydes with a chiral α,β-unsaturated aldehyde in the presence of a Jørgensen-Hayashi organocatalyst provides easy and stereocontrolled access to the cyclohexadienal backbone. This method allows for the synthesis of potential photoprotective chiral 1,3-cyclohexadienals and extra extended conjugation compounds in a simple manner.

SUBMITTER: Urosa A

PROVIDER: S-EPMC5810990 | biostudies-literature |

REPOSITORIES: biostudies-literature

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