Diastereoselective synthesis of chiral 1,3-cyclohexadienals.

ABSTRACT: A novel approach to the production of chiral 1,3-cyclohexadienals has been developed. The organocatalysed asymmetric reaction of different β-disubstituted-α,β-unsaturated aldehydes with a chiral α,β-unsaturated aldehyde in the presence of a Jørgensen-Hayashi organocatalyst provides easy and stereocontrolled access to the cyclohexadienal backbone. This method allows for the synthesis of potential photoprotective chiral 1,3-cyclohexadienals and extra extended conjugation compounds in a simple manner.

SUBMITTER: Urosa A 

PROVIDER: S-EPMC5810990 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature