Ontology highlight
ABSTRACT:
SUBMITTER: Lu KL
PROVIDER: S-EPMC5811208 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Lu Kevin L KL Nelson Jonathan O JO Watase George J GJ Warsinger-Pepe Natalie N Yamashita Yukiko M YM
eLife 20180213
rDNA loci, composed of hundreds of tandemly duplicated arrays of rRNA genes, are known to be among the most unstable genetic elements due to their repetitive nature. rDNA instability underlies aging (replicative senescence) in yeast cells, however, its contribution to the aging of multicellular organisms is poorly understood. In this study, we investigate the dynamics of rDNA loci during aging in the <i>Drosophila</i> male germline stem cell (GSC) lineage, and show that rDNA copy number decrease ...[more]