Ontology highlight
ABSTRACT:
SUBMITTER: Lopez-Baez JC
PROVIDER: S-EPMC5811212 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Lopez-Baez Juan Carlos JC Simpson Daniel J DJ LLeras Forero Laura L Zeng Zhiqiang Z Brunsdon Hannah H Salzano Angela A Brombin Alessandro A Wyatt Cameron C Rybski Witold W Huitema Leonie F A LFA Dale Rodney M RM Kawakami Koichi K Englert Christoph C Chandra Tamir T Schulte-Merker Stefan S Hastie Nicholas D ND Patton E Elizabeth EE
eLife 20180206
Regenerative therapy for degenerative spine disorders requires the identification of cells that can slow down and possibly reverse degenerative processes. Here, we identify an unanticipated wound-specific notochord sheath cell subpopulation that expresses Wilms Tumor (WT) 1b following injury in zebrafish. We show that localized damage leads to Wt1b expression in sheath cells, and that <i>wt1b</i><sup>+</sup>cells migrate into the wound to form a stopper-like structure, likely to maintain structu ...[more]