Ontology highlight
ABSTRACT:
SUBMITTER: Espino Guarch M
PROVIDER: S-EPMC5811215 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
eLife 20180122
Age-related hearing loss (ARHL) is the most common sensory deficit in the elderly. The disease has a multifactorial etiology with both environmental and genetic factors involved being largely unknown. SLC7A8/SLC3A2 heterodimer is a neutral amino acid exchanger. Here, we demonstrated that SLC7A8 is expressed in the mouse inner ear and that its ablation resulted in ARHL, due to the damage of different cochlear structures. These findings make SLC7A8 transporter a strong candidate for ARHL in humans ...[more]