Ontology highlight
ABSTRACT:
SUBMITTER: Jiang X
PROVIDER: S-EPMC5811261 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Jiang Xuan X Wooderchak-Donahue Whitney L WL McDonald Jamie J Ghatpande Prajakta P Baalbaki Mai M Sandoval Melissa M Hart Daniel D Clay Hilary H Coughlin Shaun S Lagna Giorgio G Bayrak-Toydemir Pinar P Hata Akiko A
Science signaling 20180116 513
The transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) family of cytokines critically regulates vascular morphogenesis and homeostasis. Impairment of TGF-β or BMP signaling leads to heritable vascular disorders, including hereditary hemorrhagic telangiectasia (HHT). Drosha, a key enzyme for microRNA (miRNA) biogenesis, also regulates the TGF-β and BMP pathway through interaction with Smads and their joint control of gene expression through miRNAs. We report that mice lacki ...[more]