Dataset Information

IDO Immune Status after Chemoradiation May Predict Survival in Lung Cancer Patients.

ABSTRACT: Host immunity influences the impact of radiotherapy (RT) in cancer, but mechanistic connections remain obscure. In this study, we investigated the relationship of indoleamine 2,3-dioxygenase (IDO) systemic activity on clinical outcomes in RT-treated non-small cell lung cancer (NSCLC). IDO-mediated production of kynurenine and the kynurenine:tryptophan ratio in patient blood serum were determined for stage III NSCLC patients at times before, during, and after RT administration and then correlated to overall survival (OS), progression-free survival, and disease progression rate in patients. We found the impact of RT on these serum IDO markers to be heterogeneous in patients. On average, kynurenine:tryptophan ratios were reduced during RT but restored after RT. Notably, both baseline levels of kynurenine:tryptophan and changes in the levels of kynurenine after RT were significantly associated with OS. When combined, favorable change and favorable baseline corresponded with very long-term OS (median OS was not reached after 57 months of median follow-up). Favorable change combined with unfavorable baseline still corresponded with a lack of distant metastases. Our results suggest that RT alters IDO-mediated immune status in NSCLC patients and that changes in this serum biomarker may be useful to predict outcomes and perhaps personalize RT dosage to improve survival.Significance: Radiotherapy appears to influence systemic IDO activity and to exert a significant impact on metastatic risk and overall survival, with possible implications for defining a biomarker to optimize radiation dose in patients to improve outcomes. Cancer Res; 78(3); 809-16. ©2017 AACR.

SUBMITTER: Wang W

PROVIDER: S-EPMC5811356 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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IDO Immune Status after Chemoradiation May Predict Survival in Lung Cancer Patients.

Wang Weili W Huang Lei L Jin Jian-Yue JY Jolly Shruti S Zang Yong Y Wu Huanmei H Yan Li L Pi Wenhu W Li Lang L Mellor Andrew L AL Kong Feng-Ming Spring FS

Cancer research 20171108 3

Host immunity influences the impact of radiotherapy (RT) in cancer, but mechanistic connections remain obscure. In this study, we investigated the relationship of indoleamine 2,3-dioxygenase (IDO) systemic activity on clinical outcomes in RT-treated non-small cell lung cancer (NSCLC). IDO-mediated production of kynurenine and the kynurenine:tryptophan ratio in patient blood serum were determined for stage III NSCLC patients at times before, during, and after RT administration and then correlated ...[more]

PMID: 29118088

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Dataset Information

IDO Immune Status after Chemoradiation May Predict Survival in Lung Cancer Patients.

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IDO Immune Status after Chemoradiation May Predict Survival in Lung Cancer Patients.

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