Dataset Information

Murine pulmonary imaging at 7T: T2* and T1 with anisotropic UTE.

ABSTRACT: PURPOSE:To measure the T2* and T1 of mouse lung at 7T via anisotropic-resolution radial ultrashort echo-time imaging with ellipsoidal k-space coverage. METHODS:Ellipsoidal field-of-view was created by expanding uniform spherical k-space coverage. The effects of T2* and ellipsoidal sampling on image resolution were investigated by using point-spread-function analysis and resolution phantoms. Finally, this ellipsoidal sampling approach was used to measure the lung T2* and T1 of healthy C57BL/6 mice at the increasingly common preclinical field strength of 7T. RESULTS:Lung parenchyma T2* of 17- to 23-week-old mice at 7T was 0.395?±?0.033 ms. T1 of lung and left- and right-heart ventricles was 1452.5?±?87.0 ms, 1810.5?±?54.6 ms, and 1602.6?±?120.9 ms, respectively. Ellipsoidal k-space sampling provides enhanced resolution for a fixed scanning time or provides equivalent (although anisotropic) spatial resolution with reduced scanning times, while simultaneously avoiding fold-in artifacts. CONCLUSION:Using these techniques, the first T2* and T1 measures of mouse lung at 7T are reported. Ultrashort echo-time imaging with ellipsoidal k-space coverage significantly increases in-plane resolution without increasing scanning time, or equivalently, decreases scanning time while maintaining equivalent in-plane resolution. Magn Reson Med 79:2254-2264, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

SUBMITTER: Guo J

PROVIDER: S-EPMC5811363 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Murine pulmonary imaging at 7T: T2* and T<sub>1</sub> with anisotropic UTE.

Guo Jinbang J Cao Xuefeng X Cleveland Zackary I ZI Woods Jason C JC

Magnetic resonance in medicine 20170815 4

<h4>Purpose</h4>To measure the T2* and T<sub>1</sub> of mouse lung at 7T via anisotropic-resolution radial ultrashort echo-time imaging with ellipsoidal k-space coverage.<h4>Methods</h4>Ellipsoidal field-of-view was created by expanding uniform spherical k-space coverage. The effects of T2* and ellipsoidal sampling on image resolution were investigated by using point-spread-function analysis and resolution phantoms. Finally, this ellipsoidal sampling approach was used to measure the lung T2* and ...[more]

PMID: 28812309

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Project description:An anterior cruciate ligament (ACL) injury greatly increases the risk for premature knee osteoarthritis (OA). Improved diagnosis and staging of early disease are needed to develop strategies to delay or prevent disabling OA.Novel magnetic resonance imaging (MRI) ultrashort echo time (UTE)-T2(*) mapping was evaluated against clinical metrics of cartilage health in cross-sectional and longitudinal studies of human participants before and after ACL reconstruction (ACLR) to show reversible deep subsurface cartilage and meniscus matrix changes.Cohort study (diagnosis/prognosis); Level of evidence, 2.Forty-two participants (31 undergoing anatomic ACLR; 11 uninjured) underwent 3-T MRI inclusive of a sequence capturing short and ultrashort T2 signals. An arthroscopic examination of the medial meniscus was performed, and modified Outerbridge grades were assigned to the central and posterior medial femoral condyle (cMFC and pMFC, respectively) of ACL-reconstructed patients. Two years after ACLR, 16 patients underwent the same 3-T MRI. UTE-T2(*) maps were generated for the posterior medial meniscus (pMM), cMFC, pMFC, and medial tibial plateau (MTP). Cross-sectional evaluations of UTE-T2(*) and arthroscopic data along with longitudinal analyses of UTE-T2(*) changes were performed.Arthroscopic grades showed that 74% (23/31) of ACL-reconstructed patients had intact cMFC cartilage (Outerbridge grade 0 and 1) and that 90% (28/31) were Outerbridge grade 0 to 2. UTE-T2(*) values in deep cMFC and pMFC cartilage varied significantly with injury status and arthroscopic grade (Outerbridge grade 0-2: n = 39; P = .03 and .04, respectively). Pairwise comparisons showed UTE-T2(*) differences between uninjured controls (n = 11) and patients with arthroscopic Outerbridge grade 0 for the cMFC (n = 12; P = .01) and arthroscopic Outerbridge grade 1 for the pMFC (n = 11; P = .01) only and not individually between arthroscopic Outerbridge grade 0, 1, and 2 of ACL-reconstructed patients (P > .05). Before ACLR, UTE-T2(*) values of deep cMFC and pMFC cartilage of ACL-reconstructed patients were a respective 43% and 46% higher than those of uninjured controls (14.1 ± 5.5 vs 9.9 ± 2.3 milliseconds [cMFC] and 17.4 ± 7.0 vs 11.9 ± 2.4 milliseconds [pMFC], respectively; P = .02 for both). In longitudinal analyses, preoperative elevations in UTE-T2(*) values in deep pMFC cartilage and the pMM in those with clinically intact menisci decreased to levels similar to those in uninjured controls (P = .02 and .005, respectively), suggestive of healing. No decrease in UTE-T2(*) values for the MFC and new elevation in UTE-T2(*) values for the submeniscus MTP were observed in those with meniscus tears.This study shows that novel UTE-T2(*) mapping demonstrates changes in cartilage deep tissue health according to joint injury status as well as a potential for articular cartilage and menisci to heal deep tissue injuries. Further clinical studies of UTE-T2(*) mapping are needed to determine if it can be used to identify joints at risk for rapid degeneration and to monitor effects of new treatments to delay or prevent the development of OA.

Dataset Information

Murine pulmonary imaging at 7T: T2* and T1 with anisotropic UTE.

Publications

Murine pulmonary imaging at 7T: T2* and T<sub>1</sub> with anisotropic UTE.

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