Ontology highlight
ABSTRACT:
SUBMITTER: Saranchova I
PROVIDER: S-EPMC5811448 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Scientific reports 20180213 1
Type 2 innate lymphoid cells (ILC2) potentiate immune responses, however, their role in mediating adaptive immunity in cancer has not been assessed. Here, we report that mice genetically lacking ILC2s have significantly increased tumour growth rates and conspicuously higher frequency of circulating tumour cells (CTCs) and resulting metastasis to distal organs. Our data support the model that IL-33 dependent tumour-infiltrating ILC2s are mobilized from the lungs and other tissues through chemoatt ...[more]