The small GTPase RhoU lays downstream of JAK/STAT signaling and mediates cell migration in multiple myeloma.

ABSTRACT: Multiple myeloma is a post-germinal center B-cell neoplasm, characterized by the proliferation of malignant bone marrow plasma cells, whose survival and proliferation is sustained by growth factors and cytokines present in the bone marrow microenvironment. Among them, IL-6 triggers the signal downstream of its receptor, leading to the activation of the JAK/STAT pathway. The atypical GTPase RhoU lays downstream of STAT3 transcription factor and could be responsible for mediating its effects on cytoskeleton dynamics. Here we demonstrate that RHOU is heterogeneously expressed in primary multiple myeloma cells and significantly modulated with disease progression. At the mRNA level, RHOU expression in myeloma patients correlated with the expression of STAT3 and its targets MIR21 and SOCS3. Also

SUBMITTER: Canovas Nunes S 

PROVIDER: S-EPMC5811530 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature