Ontology highlight
ABSTRACT:
SUBMITTER: Hara R
PROVIDER: S-EPMC5811625 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Hara Ryotaro R Hirai Kengo K Suzuki Shin S Kino Kuniki K
Scientific reports 20180213 1
Amide bond formation serves as a fundamental reaction in chemistry, and is practically useful for the synthesis of peptides, food additives, and polymers. However, current methods for amide bond formation essentially generate wastes and suffer from poor atom economy under harsh conditions. To solve these issues, we demonstrated an alternative synthesis method for diverse tryptophyl-N-alkylamides by the combination of the first adenylation domain of tyrocidine synthetase 1 with primary or seconda ...[more]