Ontology highlight
ABSTRACT:
SUBMITTER: Reginsson GW
PROVIDER: S-EPMC5811785 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Addiction biology 20170223 1
We use polygenic risk scores (PRSs) for schizophrenia (SCZ) and bipolar disorder (BPD) to predict smoking, and addiction to nicotine, alcohol or drugs in individuals not diagnosed with psychotic disorders. Using PRSs for 144 609 subjects, including 10 036 individuals admitted for in-patient addiction treatment and 35 754 smokers, we find that diagnoses of various substance use disorders and smoking associate strongly with PRSs for SCZ (P = 5.3 × 10<sup>-50</sup> -1.4 × 10<sup>-6</sup> ) and BPD ...[more]