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Simple sugars to complex disease--mucin-type O-glycans in cancer.

ABSTRACT: Mucin-type O-glycans are a class of glycans initiated with N-acetylgalactosamine (GalNAc) ?-linked primarily to Ser/Thr residues within glycoproteins and often extended or branched by sugars or saccharides. Most secretory and membrane-bound proteins receive this modification, which is important in regulating many biological processes. Alterations in mucin-type O-glycans have been described across tumor types and include expression of relatively small-sized, truncated O-glycans and altered terminal structures, both of which are associated with patient prognosis. New discoveries in the identity and expression of tumor-associated O-glycans are providing new avenues for tumor detection and treatment. This chapter describes mucin-type O-glycan biosynthesis, altered mucin-type O-glycans in primary tumors, including mechanisms for structural changes and contributions to the tumor phenotype, and clinical approaches to detect and target altered O-glycans for cancer treatment and management.

SUBMITTER: Kudelka MR

PROVIDER: S-EPMC5812724 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Simple sugars to complex disease--mucin-type O-glycans in cancer.

Kudelka Matthew R MR Ju Tongzhong T Heimburg-Molinaro Jamie J Cummings Richard D RD

Advances in cancer research 20150207

Mucin-type O-glycans are a class of glycans initiated with N-acetylgalactosamine (GalNAc) α-linked primarily to Ser/Thr residues within glycoproteins and often extended or branched by sugars or saccharides. Most secretory and membrane-bound proteins receive this modification, which is important in regulating many biological processes. Alterations in mucin-type O-glycans have been described across tumor types and include expression of relatively small-sized, truncated O-glycans and altered termin ...[more]

PMID: 25727146

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