Ontology highlight
ABSTRACT:
SUBMITTER: Tao P
PROVIDER: S-EPMC5812732 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Tao Pan P Wu Xiaorong X Rao Venigalla V
Science advances 20180214 2
Bacteria and bacteriophages arm themselves with various defensive and counterdefensive mechanisms to protect their own genome and degrade the other's. CRISPR (clustered regularly interspaced short palindromic repeat)-Cas (CRISPR-associated) is an adaptive bacterial defense mechanism that recognizes short stretches of invading phage genome and destroys it by nuclease attack. Unexpectedly, we discovered that the CRISPR-Cas system might also accelerate phage evolution. When <i>Escherichia coli</i> ...[more]