Ontology highlight
ABSTRACT:
SUBMITTER: Saita S
PROVIDER: S-EPMC5813258 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Saita Shotaro S Tatsuta Takashi T Lampe Philipp A PA König Tim T Ohba Yohsuke Y Langer Thomas T
The EMBO journal 20180104 4
Intramembrane-cleaving peptidases of the rhomboid family regulate diverse cellular processes that are critical for development and cell survival. The function of the rhomboid protease PARL in the mitochondrial inner membrane has been linked to mitophagy and apoptosis, but other regulatory functions are likely to exist. Here, we identify the START domain-containing protein STARD7 as an intramitochondrial lipid transfer protein for phosphatidylcholine. We demonstrate that PARL-mediated cleavage du ...[more]