Ontology highlight
ABSTRACT:
SUBMITTER: Cosin-Roger J
PROVIDER: S-EPMC5814018 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Cosin-Roger Jesus J Spalinger Marianne R MR Ruiz Pedro A PA Stanzel Claudia C Terhalle Anne A Wolfram Lutz L Melhem Hassan H Atrott Kirstin K Lang Silvia S Frey-Wagner Isabelle I Fried Michael M Scharl Michael M Hausmann Martin M Rogler Gerhard G
PloS one 20180215 2
Gp96 is an endoplasmic reticulum chaperone for multiple protein substrates. Its lack in intestinal macrophages of Crohn's disease (CD) patients is correlated with loss of tolerance against the host gut flora. Gp96 has been stablished to be an essential chaperone for Toll-like receptors (TLRs). We studied the impact of gp96-knockdown on TLR-function in macrophages. TLR2 and TLR4 expression was only decreased but not abolished when gp96 was knocked-down in cell lines, whereas in a monocyte/macroph ...[more]