A maximum-entropy model for predicting chromatin contacts.
Ontology highlight
ABSTRACT:
SUBMITTER: Farre P
PROVIDER: S-EPMC5814105 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
A maximum-entropy model for predicting chromatin contacts.
PLoS computational biology 20180205 2
The packaging of DNA inside a nucleus shows complex structure stabilized by a host of DNA-bound factors. Both the distribution of these factors and the contacts between different genomic locations of the DNA can now be measured on a genome-wide scale. This has advanced the development of models aimed at predicting the conformation of DNA given only the locations of bound factors-the chromatin folding problem. Here we present a maximum-entropy model that is able to predict a contact map represent ...[more]
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