Ontology highlight
ABSTRACT:
SUBMITTER: Decker F
PROVIDER: S-EPMC5814149 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Decker Franziska F Oriola David D Dalton Benjamin B Brugués Jan J
eLife 20180111
Regulation of size and growth is a fundamental problem in biology. A prominent example is the formation of the mitotic spindle, where protein concentration gradients around chromosomes are thought to regulate spindle growth by controlling microtubule nucleation. Previous evidence suggests that microtubules nucleate throughout the spindle structure. However, the mechanisms underlying microtubule nucleation and its spatial regulation are still unclear. Here, we developed an assay based on laser ab ...[more]