Ontology highlight
ABSTRACT:
SUBMITTER: Umbaugh CS
PROVIDER: S-EPMC5814187 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Umbaugh Charles Samuel CS Diaz-Quiñones Adriana A Neto Manoel Figueiredo MF Shearer Joseph J JJ Figueiredo Marxa L ML
Oncotarget 20171213 5
Laminin receptor (67 LR) is a 67 kDa protein derived from a 37 kDa precursor (37 LR). 37/67 LR is a strong clinical correlate for progression, aggression, and chemotherapeutic relapse of several cancers including breast, prostate, and colon. The ability of 37/67 LR to promote cancer cell aggressiveness is further increased by its ability to transduce physiochemical and mechanosensing signals in endothelial cells and modulate angiogenesis. Recently, it was demonstrated that 37/67 LR modulates the ...[more]