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Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization.

ABSTRACT: Cerebral malaria is a life-threatening complication of Plasmodia infection and a major cause of child mortality in Sub-Saharan Africa. We report that protection from experimental cerebral malaria in the rodent model is obtained by a single intravenous or subcutaneous whole-parasite immunization. Whole-parasite immunization with radiation-attenuated sporozoites was equally protective as immunization with non-attenuated sporozoites under chemoprophylaxis. Both immunization regimens delayed the development of blood-stage parasites, but differences in cellular and humoral immune mechanisms were observed. Single-dose whole-parasite vaccination might serve as a relatively simple and feasible immunization approach to prevent life-threatening cerebral malaria.

SUBMITTER: Heiss K

PROVIDER: S-EPMC5814423 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization.

Heiss Kirsten K Maier Marion Irmgard MI Hoffmann Angelika A Frank Roland R Bendszus Martin M Mueller Ann-Kristin AK Pfeil Johannes J

Scientific reports 20180215 1

Cerebral malaria is a life-threatening complication of Plasmodia infection and a major cause of child mortality in Sub-Saharan Africa. We report that protection from experimental cerebral malaria in the rodent model is obtained by a single intravenous or subcutaneous whole-parasite immunization. Whole-parasite immunization with radiation-attenuated sporozoites was equally protective as immunization with non-attenuated sporozoites under chemoprophylaxis. Both immunization regimens delayed the dev ...[more]

PMID: 29449638

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