Ontology highlight
ABSTRACT:
SUBMITTER: Oleinika K
PROVIDER: S-EPMC5814456 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Oleinika K K Rosser E C EC Matei D E DE Nistala K K Bosma A A Drozdov I I Mauri C C
Nature communications 20180215 1
Regulatory B cells (Breg) express high levels of CD1d that presents lipid antigens to invariant natural killer T (iNKT) cells. The function of CD1d in Breg biology and iNKT cell activity during inflammation remains unclear. Here we show, using chimeric mice, cell depletion and adoptive cell transfer, that CD1d-lipid presentation by Bregs induces iNKT cells to secrete interferon (IFN)-γ to contribute, partially, to the downregulation of T helper (Th)1 and Th17-adaptive immune responses and amelio ...[more]