Ontology highlight
ABSTRACT:
SUBMITTER: Chen G
PROVIDER: S-EPMC5814808 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Chen Guo G Chen Jianxiang J Qiao Yiting Y Shi Yaru Y Liu Wei W Zeng Qi Q Xie Hui H Shi Xiaorui X Sun Youwei Y Liu Xu X Li Tongyu T Zhou Liqian L Wan Jianqin J Xie Tian T Wang Hangxiang H Wang Fu F
Nucleic acids research 20180201 3
Homologous recombination (HR), which mediates the repair of DNA double-strand breaks (DSB), is crucial for maintaining genomic integrity and enhancing survival in response to chemotherapy and radiotherapy in human cancers. However, the mechanisms of HR repair in treatment resistance for the improvement of cancer therapy remains unclear. Here, we report that the zinc finger protein 830 (ZNF830) promotes HR repair and the survival of cancer cells in response to DNA damage. Mechanistically, ZNF830 ...[more]