Unknown

Dataset Information

0

Subclinical Atherosclerosis, Statin Eligibility, and Outcomes in African American Individuals: The Jackson Heart Study.


ABSTRACT: Importance:Modern prevention guidelines substantially increase the number of individuals who are eligible for treatment with statins. Efforts to refine statin eligibility via coronary calcification have been studied in white populations but not, to our knowledge, in large African American populations. Objective:To compare the relative accuracy of US Preventive Services Task Force (USPSTF) and American College of Cardiology/American Heart Association (ACC/AHA) recommendations in identifying African American individuals with subclinical and clinical atherosclerotic cardiovascular disease (ASCVD). Design, Setting, and Participants:In this prospective, community-based study, 2812 African American individuals aged 40 to 75 years without prevalent ASCVD underwent assessment of ASCVD risk. Of these, 1743 participants completed computed tomography. Main Outcomes and Measures:Nonzero coronary artery calcium (CAC) score, abdominal aortic calcium score, and incident ASCVD (ie, myocardial infarction, ischemic stroke, or fatal coronary heart disease). Results:Of the 2812 included participants, the mean (SD) age at baseline was 55.4 (9.4) years, and 1837 (65.3%) were female. The USPSTF guidelines captured 404 of 732 African American individuals (55.2%) with a CAC score greater than 0; the ACC/AHA guidelines identified 507 individuals (69.3%) (risk difference, 14.1%; 95% CI, 11.2-17.0; P?

SUBMITTER: Shah RV 

PROVIDER: S-EPMC5815027 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

Subclinical Atherosclerosis, Statin Eligibility, and Outcomes in African American Individuals: The Jackson Heart Study.

Shah Ravi V RV   Spahillari Aferdita A   Mwasongwe Stanford S   Carr J Jeffrey JJ   Terry James G JG   Mentz Robert J RJ   Addison Daniel D   Hoffmann Udo U   Reis Jared J   Freedman Jane E JE   Lima Joao A C JAC   Correa Adolfo A   Murthy Venkatesh L VL  

JAMA cardiology 20170601 6


<h4>Importance</h4>Modern prevention guidelines substantially increase the number of individuals who are eligible for treatment with statins. Efforts to refine statin eligibility via coronary calcification have been studied in white populations but not, to our knowledge, in large African American populations.<h4>Objective</h4>To compare the relative accuracy of US Preventive Services Task Force (USPSTF) and American College of Cardiology/American Heart Association (ACC/AHA) recommendations in id  ...[more]

Similar Datasets

| S-EPMC5121048 | biostudies-literature
| S-EPMC4523273 | biostudies-literature
| S-EPMC5310994 | biostudies-literature
| S-EPMC6153048 | biostudies-literature
| S-EPMC3025639 | biostudies-literature
| S-EPMC8052931 | biostudies-literature
| S-EPMC5141947 | biostudies-literature
| S-EPMC5146707 | biostudies-literature
| S-EPMC5543722 | biostudies-literature
| S-EPMC6931894 | biostudies-literature