Ontology highlight
ABSTRACT:
SUBMITTER: Dou W
PROVIDER: S-EPMC5815066 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Dou Weiwang W Zhu Jianhua J Wang Tanjun T Wang Wei W Li Han H Chen Xin X Guan Wenjun W
FEMS yeast research 20160419 4
Pdr5p is a major ATP-binding cassette (ABC) transporter in Saccharomyces cerevisiae. It displays a sequence and functional homology to the pathogenic Candida albicans multidrug resistance protein Cdr1p. The transmembrane helices of Pdr5p act in substrate recognition, binding, translocation and eventual removal of toxic substances out of the plasma membrane via the formation of a binding pocket. In this study, we identify two novel Pdr5 mutants (E574K and E580K), which exhibit impaired substrate ...[more]